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Knockdown of GGCT significantly inhibited tumor growth, depleted GSH, and elevated ROS levels, whereas overexpression of GGCT exerted the opposite effects

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7 Inhibitory effect of metformin on glioma stem cells An international study on the combination of drugs for glioma patients found that the combination of metformin and sorafenib could improve the therapeutic effect of GSC cell lines, and also reduce the proliferation of glioma stem cells