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Research in aging mouse models shows that MOTS-c administration suppresses SASP markers and reduces the burden of senescent cells in metabolically active tissues [2]
Although biologically notable, transcriptomic shifts do not necessarily indicate tissue rejuvenation or restored function in humans
Eisenberg T, Knauer H, Schauer A, Bttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Frhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F (2009) Induction of autophagy by spermidine promotes longevity
To be clear, this has nothing to do with any safety concerns on the FDAs part
Papaccio, F., DArino, A., Caputo, S., & Bellei, B
The stuff that our brains are made of are notoriously complex and work in yet-to-be-fully understood ways
