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In the 1960s, manufacturers introduced short-term weight-loss medications such as phentermine, benzphetamine, and diethylpropion, but researchers did not collect long-term safety data (8)
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CrossRef Integrated network toxicology, molecular docking and transcriptomics reveal the mechanistic role of phthalate esters in metabolic disease pathogenesis Yuancheng Shao, Qi Liu, Yicheng Jiang, Gang Zhou, Xihan Gu, Shufan Zhang, Shuai Chen, Jiaming Xue, Liming Tang Food and Chemical Toxicology .2026
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4.6.3 Unknown risks of long-term supplementation Although BCAA supplementation is generally safe in the short term, the risks of long-term high-dose use have not been adequately studied
