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8-12 weeks on followed by 4-8 weeks off is standard
At 2.4 mg weekly, average weight loss reached about 15% over 68 weeks. Response varied widely: 86% lost at least 5%, 69% lost 10%, half lost 15%, and about one-third lost 20%. These results describe that cohort rather than a universal forecast
Semaglutide is a subcutaneous injection, meaning it goes into the fatty tissue just under the skin, not into a muscle or vein
Last reviewed/updated: February 18, 2026
Doctors typically limit use to 12 weeks or less
Why am I not losing weight on Mounjaro initially
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