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however, unraveling endogenous circuits location in mediating this beneficial effect has been challenging

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While early findings have generated considerable scientific interest, much of the current evidence remains limited to laboratory and preclinical research

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The rationale: GHRH-receptor agonism plus ghrelin-receptor agonism produces a synergistic GH pulse larger than either agent alone, as demonstrated in earlier GHRH-plus-GHRP combination studies [7]