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The infection gradually spreads until deeper and more extensive tissues are infected, eventually occluding small veins and arteries, which leads to the ischemic necrosis of all tissue layers from the dermis to the fascia 506 (Fig
2023 Jul 21;29(27):4289-4316
15 , e1853 (2022)
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This non-linearity arises because multiple redox, hormonal, and metabolic signaling pathways converge on shared transcriptional regulators, biosynthetic enzymes, and precursor pools, redistributing metabolic flux among competing phenylpropanoid outputs rather than uniformly increasing activity across the pathway (Atkinson et al., 2013)
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