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When will drugs like retatrutide, CagriSema, and orforglipron be available
In ATTAIN-1 , the highest dose of orforglipron (36 mg daily) produced average weight loss of 12.4% (27.3 pounds) at 72 weeks
Lowering the risk of worsening kidney disease in patients with chronic kidney disease (CKD) and type 2 diabetes
One of their most compelling benefits lies in renal protection
Similar concerns have been seen with lipid outcomes with an increase in total cholesterol after cessation of semaglutide to near pretreatment levels and loss of around two-thirds of the benefit in triglycerides, while positive changes in LDL-C and HDL-C were more modest but appeared more durable (Table 2) [73]
(71) indeed reported that chronic treatment with GLP-1RA exendin 4 (Ex4) in rats decreased renal cortical ANG II content and urinary excretion of AGT, while blockade of GLP-1 receptor with exendin 9 (Ex9) exerted opposite effects
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