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The honest answer is: we do not know

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Among these, the class III phosphatidylinositol 3-kinase (PI3K-III) complex, comprising Vps34, Beclin-1, Vps15 and Atg14, is responsible for generating phosphatidylinositol 3-phosphate (PI3P) (Klionsky et al., 2021)

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This nanosystem co-delivers gemcitabine, which depletes MDSCs, and D-1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase (IDO), an enzyme that promotes T cell suppression

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