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For example, vegans/vegetarians and people suffering from atrophic gastritis or pernicious anaemia use B12 injections

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337,338 Structural mitochondrial abnormalities such as disrupted cristae are widely documented in FTLD-TDP, AD, mixed AD/PD, and HD, linking altered mitochondrial architecture to impaired ATP production, calcium dysregulation, synaptic dysfunction, and eventual neuronal death

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When methionine availability increases, SAM levels rise and promotes the dissociation of the SAMTOR-GATOR1 complex