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Although Asp29Asn was unique to GD_SS1.2 evolution, Asn143Asp and Pro174Leu were present in both trajectories and likely contributed to increased substrate flexibility

Musculoskeletal Research: Studied in tendon, ligament, and muscle injury models, where it has been linked with improved angiogenesis and repair responses

This connection to iron homeostasis may have broader implications for anemia and age-related changes in blood cell production

Its sequence corresponds to a fragment of a larger protein originally identified in human gastric juice [2]

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