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The biology suggests sustained use produces sustained benefit, not just initial improvement followed by tolerance

Using GLP-1 Medications Before Bariatric Surgery Some patients use GLP-1 medications before surgery to help support pre-operative weight loss

Ongoing trials are evaluating the optimal sequencing and combination of these agents to further improve outcomes (Fig

I read a very interesting paper linking it with neuroportective effects on Alzheimers

89 OkabeM.UnnoM.HarigaeH.KakuM.OkitsuY.SasakiT.et al (2005)

MASLD pathogenesis involves complex interactions among multiple pathological processes, including excessive fatty acid accumulation, dysregulated inflammatory responses, oxidative stress, and insulin resistance