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The addition of glucagon receptor agonism introduces some theoretical safety considerations not seen with GLP-1 agonists alone

Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

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The search strategy incorporated terms related to GLP-1 receptor agonists (e.g., GLP-1, Semaglutide, Liraglutide, Exenatide) in combination with alcohol use concepts (e.g., alcohol, alcohol use disorder, binge drinking, ethanol)

26 The study encompassed 232 patients, randomized to receive oral ALC 500 mg t.i.d