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Higher doses are associated with greater appetite suppression and more pronounced gastrointestinal effects, both of which can prolong fatigue

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The FLOW trial showed a 24% reduction in major kidney events in people with type 2 diabetes and CKD, and the SMART trial showed a 52% reduction in urinary albumin leakage, a key marker of kidney damage

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A p-value of less than 0.05 was set as the threshold for clinical significance

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