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In preclinical models , this contributes to increased metabolic activity and reduced fat accumulation

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The GI absorption, BBB permeation, P-gp substrate, cytochrome P450 enzyme inhibition/induction, skin permeation are critical for the oral activity of drug molecules and these properties can be predicted

Gastrointestinal adverse events were the most frequently reported side effects across all retatrutide dose groups , and they occurred primarily during the dose escalation phase of treatment

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Nature Communications , 14 (1), 5141 Beloqui, A., Solins, M