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Hitchcock et al., 2015 showed inflammation driven thrombosis via ligation of C-type lectinlike receptor-2 (CLEC-2) on platelets using a mice model of Salmonella typhimurium infection [92]

Sequencing was performed on the DNBSEQ-G400RS platform using the G400-PE150 sequencing kit (MGI), generating paired-end reads of 150 bp

Based on the result they concluded that secretin extracts helped to lower blood glucose levels by encouraging the pancreas to secrete insulin (Zunz, La Barre

The Phase 2 readout established the dose-response signal that the Phase 3 program later confirmed at scale

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