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We have recently shown that the collateral sensitivity of resistant cells to these drugs is dependent on P-gp expression and activity, whereby stimulation of its ATPase activity triggers a rise in reactive oxygen species (ROS) leading to heightened oxidative cell death of resistance cells [14,15,16,17]

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reported reduced offtarget cytotoxicity with trastuzumabRSL3 compared to free RSL3

doi: 10.3945/ajcn.110.003483 254 SestiliP.FimognariC