A master antioxidant works best when it has a supporting cast
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Thus, considering the high abundance of lactate production mostly derived from specific gut bacterial communities such as bifidobacteria and lactobacilli, it is worthwhile to analyze the complex and context-dependent roles of lactate during UC-related gut microbiome disorders [126]
Where It Acts The primary target cells are dermal fibroblasts (the cells responsible for producing collagen, elastin, and the extracellular matrix proteins that give skin its mechanical structure) and basal keratinocytes (the proliferating cell population at the bottom of the epidermis)
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However, LOsG impaired glucose tolerances (GT), as revealed by OGTT and decreased fast plasma insulin level (Fig