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doi: 10.1056/NEJMoa2032183 20 FoxCKAuerbachPBarrientos-PrezMGiesIHalePMMarcusCet al

Key findings relevant to nausea included: Nausea was most prevalent during the dose-escalation phase and tended to diminish over time as participants adapted to the medication Higher doses were associated with higher rates of nausea and vomiting The majority of gastrointestinal events were transient and self-limiting Discontinuation due to gastrointestinal side effects occurred in a small but notable proportion of participants, particularly in higher-dose groups It should be noted that the weight-loss outcomes described above are from a Phase 2 trial and cannot be directly compared with those of licensed medicines without head-to-head data

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The retrograde FluoroGold signal in DMV was quantified for the verification of SDV 47,48,49

Thyroid hormones reversely suppress somatostatin secretion and immunoreactivity in cultured neocortical cells