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Joshua Silva, MD Nov 7, 2025 13 min read Updated: Apr 17 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD As GLP-1 and GLP-1/GIP medications such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) continue to transform medical weight management, one question comes up repeatedly: Do these medications cause muscle lossor even muscle wasting

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People on Wegovy still got Covid, and at the same rate as people randomly assigned to take a placebo

While liraglutide has also demonstrated cardiovascular benefits, semaglutide stands out with its positive impact on cardiovascular health

You would think this means that their mechanisms of action are the same, but they have some key differences