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As a synthetic structural analog of NAG, carglumic acid enhances the detoxification of ammonia by activating CPS1 in the liver [10, 11]
Acid keeps the protein away from the pH at which its net charge is lowest and aggregation is most favorable, but it also means the concentrated stock is not at physiological pH and that transferring it into a buffered medium involves a pH transition where local precipitation can occur if it is done abruptly into a small volume
Surprisingly, in the same study, an increase of sst 3 subtype was observed in AD cortex
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