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When severe, it can make toes and lower feet feel intensely cold and may be associated with color changes, pale, then blue, then red as circulation returns

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This oxidative stress links to many diseases, including diabetes, obesity, Parkinsons, cystic fibrosis, cancer and heart problems

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They are not for human or veterinary use and have not been approved by the FDA for the diagnosis, treatment, cure, or prevention of any condition.

Treatment of active Crohn's disease by exclusion diet: East Anglian Multicentre Controlled Trial