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In mouse OCTN3/SLC22A21, a sodium-independent carnitine transporter absent in humans 47,48 , the dual glutamine motif is replaced with a dual histidine motif, which is the only significant difference in residues between the carnitine/sodium sites of hOCTN2 and mOCTN3 (78.7% identity, Supplementary Fig

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MTII's non-selective binding at MC3R and MC4R makes it a pharmacological tool for dissecting melanocortin circuit functions in energy balance research