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Subsequently, the following eligibility criteria were applied: a) healthy human subjects

N Engl J Med 387(3):205216 Drant A, Blanchard C, Jacobi D (2024) Adjuvant glucose-like peptide 1 receptor agonist therapy for suboptimal weight loss after bariatric surgery: a systematic review

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doi: 10.1152/ajpregu.00520.2015 29 Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, LIR and exendin-4

We hypothesized that a positive allosteric modulator (PAM) could be used as a tool to lower this activation barrier, thereby increasing assay sensitivity and facilitating the detection of weak agonists in a cell-based functional assay

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