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It is easy to assume these are the best options because of the high milligram count
Normal saline was administered at the other two time points, and at all three time points in the control arm (in which no metformin was administered), to ensure blinding of participants and researchers
At the same time, Mounjaros price increase from September 2025 means Wegovy is now often the more cost-effective option
Thus, the main analytical sample included 2574 participants (2363 from NESDA baseline and 211 siblings) with data on MDD diagnostic status, overall depression severity, and depressive symptoms profiles and at least one of the investigated metabolites
Doses should not be doubled when titrating
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