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Together, these factors form an integrated molecular network in which NO-mediated perfusion facilitates nutrient delivery, leucine-driven mTOR activation supports muscle anabolism, and exercise-induced AMPK signaling maintains metabolic efficiencycollectively counteracting the anabolic resistance associated with aging

After 12 weeks, the HCP group showed significant improvement in skin elasticity, hydration, and roughness compared with baseline and placebo-control values

These shortcomings have promoted the emergence of noninvasive detection methods that are effective for both diagnosis and treatment

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Concurrent supplementation with L-carnitine may be considered on a case-by-case basis, with close monitoring, particularly for endurance athletes or those in an intensive recovery phase

22,56,57 Cardiovascular diseases and related risk factors (e.g., hypertension, atherosclerosis) impair blood flow to peripheral nerves, worsening neuropathic symptoms