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It is an active subject of metabolic research literature, with primary citations listed on this page

Patients should also report diarrhea that significantly impacts quality of life or prevents maintaining adequate nutrition and hydration

(PubMed) Heese P, Linnebank M, Semmler A, et al

Randomized clinical trial comparing the efficacy and safety of treatment with the once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor omarigliptin or the once-daily DPP-4 inhibitor sitagliptin in patients with type 2 diabetes inadequately controlled on metformin monotherapy

Montenero A, Kearney A, Mulugeta M, et al

Pharmacokinetics and pharmacodynamics of mibavademab (a leptin receptor agonist): results from a first-in-human phase I study