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Glucagon directly increases energy expenditure
These drugs, known as glucagon-like peptide-1 receptor agonists or GLP-1 medications, have gained attention for their role in helping people manage type 2 diabetes, and more recently, for their weight loss benefits
The absolute loss is still real, and still worth preventing, but the framing matters [7, 8]
Retatrutide (development code LY-3437943) is a synthetic peptide developed by Eli Lilly and Company designed to act simultaneously on three hormone-receptor pathways: GLP-1 (glucagonlike peptide-1) GIP (glucosedependent insulinotropic polypeptide) Glucagon receptor (GCG) nejm.org Put simply: it takes the mechanism of todays weight-loss injections and adds an extra dimension of hormonal stimulation, with the aim of significantly greater weight-loss outcomes
Since then, I've started writing publicly about being a size-inclusive physician who doesn't push my patients to lose weight