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The rubber stopper keeps coring Coring happens when the needle punches through the rubber stopper instead of cleanly piercing it, depositing a tiny rubber fragment into the solution

Microglia in ALS: the good, the bad, and the resting

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Moreno et al

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The combined activation of all three pathways is hypothesised to produce more pronounced and sustained weight reduction, though the long-term clinical implications of each receptor's contribution remain to be fully established