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But there is very little data on how the drug works in humans

Glucagon receptor activation drives hepatic fatty acid oxidation, essentially forcing the liver to burn its stored fat

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Furthermore, the nausea that some patients experience with Mounjaro may lead to dietary changes or irregular eating patterns, which can further disrupt normal digestive processes and contribute to gas accumulation

In melasma, the Wnt/-catenin pathway is involved in the regulation of fibroblast-secreted factors that modulate melanocytes activity

Primary Handling Editor: Ashley Castellanos-Jankiewicz, in collaboration with the Nature Metabolism team