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In a phase 2 study in people with obesity (without T2D), retatrutide (doses 1 to 12 mg) has led to a dose-dependent WL up to 24.2% at the end of the 48-week treatment period compared to 2.1% with placebo [81]

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as a two-electron reductant it supplies reducing equivalents to the glutathione peroxidase family, cycling to the disulfide GSSG and back through glutathione reductase and NADPH

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10.1016/j.hrtlng.2020.04.008 135 YuanR.LiY.HanS.ChenX.ChenJ.HeJ.et al (2022)