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Conversely, a consistent correlation between EGLN1 SNPs and HAPE susceptibility has been observed in multiple independent studies

( C ) Venn diagram showed that the overlap of 1551 up-regulated DEGs and 165 ROS generation-related genes led to 12 hub genes being identified (left)

Lim SH, Morris A, Li K, Fitch AC, Fast L, Goldberg L, Quesenberry M, Sprinz P, Meth B (2018) Intestinal microbiome analysis revealed dysbiosis in sickle cell disease

doi:10.1016/j.fertnstert.2008.12.062

These are plausible risk signals, not confirmed IGF-1 LR3-specific findings

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