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Medicines for obesity work best when they are combined with healthy eating, physical activity, sleep support, and long-term behavior change

Tirzepatide does not directly cause frequent urination as a primary pharmacological effect

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Metformin has shown promise owing to its anti-inflammatory and insulin-sensitizing properties

The SELECT trial (Lincoff et al., N Engl J Med, 2023) demonstrated a 20% reduction in major adverse cardiovascular events with semaglutide 2.4 mg in overweight/obese patients with established cardiovascular disease

Key Takeaways Almost all patients experience a weight loss plateau on semaglutide, usually after 36 months of treatment