Dean O, Gray KM, Villagonzalo K-A, Dodd S, Mohebbi M, Vick T, Tonge BJ, Berk M (2016) A randomised, double blind, placebo-controlled trial of a fixed dose of N-acetyl cysteine in children with autistic disorder
But prolonged exposure to high leptin causes the brain to become leptin resistant : the hypothalamus stops responding effectively to the signal, in the same way that ears habituate to background noise
This is a primary factor contributing to the development of drug resistance
Packaging can differ from U.S
Presented for research literature review only Nishikori K et al
Its worth being clear-eyed about the studys limits: it was a single-center, retrospective chart review, not a randomized trial, and nearly a third of patients discontinued the medication, most often due to gastrointestinal side effects