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McIntyre added that this is one of the most important questions in psychopharmacology and psychiatry: trying to find a fit-for-purpose treatment for lithium-induced kidney injury, which is a major problem and barrier to prescription or continuation of a treatment that's the most life saving in bipolar disorder. Investigators noted these results may provide preliminary support for GLP-1 RAs as having a protective effect on lithium-associated renal injury

Systematic review design The authors screened various electronic databases to identify clinical trials that investigated the effect of GLP-1 receptor agonists on different types of substance use disorders (alcohol, nicotine, and cocaine use disorders) in adult patients

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Schizophrenia Long-term use (up to 24 weeks) of 10003600 mg/day helped reduce negative symptoms (like low motivation, withdrawal)[1]

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