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The eventual FDA approval of the bupropion-naltrexone combination (Contrave) provided one of the first clinical demonstrations that anti-addiction medications acting on reward pathways could also reduce overeating
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This is one reason tirzepatide is of particular clinical interest in people with T2D and early kidney disease
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Weeks 5-8 : Take 0.5 mg each week
Even when appetite is significantly reduced, it is important to maintain adequate intake of: Protein (to preserve lean muscle mass and support energy) Complex carbohydrates (to sustain blood glucose levels) Iron, B12, and folate (to help prevent nutritional anaemia if deficiency is suspected, speak to a GP for testing before starting supplements) Fluids aim for around 68 drinks per day (approximately 1.21.5 litres), in line with NHS hydration guidance
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