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The efficacy of the new pharmacotherapies will allow clinicians to treat obesity towards individualised treatment targets, similar to what is happening with other chronic diseases such as T2D or dyslipidaemia

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doi: 10.3389/bjbs.2021.10191 41 KhanA.AhsanO.WeiD

While no clinical evidence demonstrates DSIP tolerance development, cycling maintains receptor sensitivity and allows residual effects to be monitored during the off period