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Reducing occupational stress with a B-vitamin focussed intervention: a randomized clinical trial: study protocol
References Costell M, et al
Malagi, R
[] In late 2024, the ongoing Phase III ESSENCE trial (NCT04822181) assessing once-weekly 2.4 mg semaglutide in adults with MASH and moderate to advanced liver fibrosis (F2F3) revealed fibrosis improvement without worsening steatohepatitis in 37% of patients receiving semaglutide, compared to 22.5% in the placebo group, with an estimated difference in the proportion of responders (EDP) of 14.4%, making it the first study which confirmed semaglutides efficacy in improving liver fibrosis
The table records it as having no RCT support and being off-label, with typical weight loss listed as unknown and likely reduced
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