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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

Smith BH, Campbell A, Linksted P et al (2013) Cohort profile: Generation Scotland: Scottish Family Health Study (GS:SFHS)

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This distinction affects how the compound is absorbed, metabolized, and utilized in the body

These factors create oxidative stress, which can deplete your glutathione stores faster than your body can replenish them

it is used as a cosmetic ingredient and a research compound, and legal status varies by jurisdiction