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and step 3: stirring to dissolve and clarify the prepared solution, adding water for injection to full amount, and adjusting pH to 6.8 with 10% sodium hydroxide solution

Community sources variously attribute it to dose, to the DMSO carrier in transdermal use, or to vascular effects, with no way to confirm cause in self-reports

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- It is recommended to do a skin sensitivity test before first use

10.2903/j.efsa.2014.3846 EFSA J

Pain scores may decrease by 30-60%, sleep becomes more restorative, and daily activities become more manageable