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It was reclassified from FDA Category 2 (restricted) back to Category 1 (compoundable) following HHS Secretary RFK Jr.s announcement on February 27, 2026

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Folate deficiency in a mother increases the risk of neural tube defects including spina bifida, but the link to autism is unclear

Results of this study have shown that carriers of GSTA1 CC genotype, with the highest expression of GSTA1 enzyme, are in increased risk of developing ASD when compared to individuals with GSTA1 CT and TT genotype

Most side effects resolve within a few hours to a few days

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