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Differences in treatment response may be indicative of differences in etiologies and mechanisms, like neuroinflammation, changes in the neuroendocrine system, or alterations in the gut microbiome (Mousten et al., 2022)
When GLP-1 levels rise, the stomach empties more slowly, insulin secretion increases, glucagon (which raises blood sugar) decreases, and many people notice that constant food noise in their head quiets down
10.1136/gutjnl-2023-331090 Gut
Earlier initiation is reshaping patient journeys: Patients are starting GLP1 therapy within weeks of diagnosis, underscoring the need for streamlined access pathways and payer alignment to reduce delays, especially in Medicare populations
A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression
Similarly, a liver condition called metabolic-associated steatohepatitis (MASH) did not have any FDA-approved medications until 2024
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