Robbins MS et al
Interestingly, the C-terminus of exendin-4 may be required to facilitate formation of high order GLP-1R oligomers through interaction with neighbouring GLP-1R protomers in trans (Koole et al ., 2017)
N Engl J Med 375:18341844 Thompson AM, Trujillo JM (2015) Dulaglutide: the newest GLP-1 receptor agonist for the management of type 2 diabetes
The approval covers a combination regimen of Akeega with prednisone and is based on data from the Phase III MAGNITUDE study, a randomized, double-blinded and placebo-controlled trial with 765 participants
In the later period, new users in both SGLT2i and GLP-1 RA cohorts were older, use of medications for type 2 diabetes was less intensive, and metabolic control was better, and although more patients had renal function assessed, patients had more severe CKD (stage 3: 44.052.1% vs
But the real story is more comple