Source: Northwestern University Northwestern Medicine scientists have identified a safety concern associated with GLP-1 drugs
Most protocols run for 3 to 6 months followed by a 1 to 2 month break
In a healthy system, this helps you feel full longer and ensures that nutrients are absorbed efficiently
Postural Orthostatic Tachycardia Syndrome (POTS) A POTS patient who needed to take 2-3 xs more time to do her college work, reported she no longer had brain fog and was able to do her work in a third of the time
Common side effects for both include: Mild injection-site reactions (small bump or redness, resolves within hours) Transient water retention in the first 1-2 weeks Vivid dreams in the first week (often a positive sign of deepening REM cycles) Occasional brief flushing sensation immediately after injection more common with CJC-1295/Ipamorelin Mild tingling or fatigue in the first few doses, typically resolves quickly Less common but serious considerations include effects on glucose tolerance (worth monitoring if you're insulin-resistant or diabetic), the potential for joint discomfort if dose is too high, and any contraindications related to active cancer, severe pituitary issues, or specific medications
The medications are known as GLP-1 agonists and include popular brands such as Wegovy, Ozempic, Rybelusus and Saxenda