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The decreased NAMPT might be due to the chronic inflammation and impaired circadian clock during aging
372 PLGA-PEG nanoparticle-based systems efficiently deliver HECTD2 inhibitors or KEAP1 stabilizers to inhibit HECTD2-mediated KEAP1 degradation, restoring KEAP1/NRF2 balance, suppressing antioxidant responses, and reversing lenvatinib resistance in HCC
Some individuals may respond more favorably than others, necessitating adjustments to the treatment duration
Ethics declarations Competing Interests The authors declare no competing interests
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PMID 34288673
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