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Immunochemical analysis of sulfonamide drug allergy: identification of sulfamethoxazole-substituted human serum proteins

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Unlike phosphodiesterase inhibitors, the compound acts centrally via hypothalamic and limbic pathway modulation rather than through direct peripheral vascular mechanisms a pharmacological distinction that has made PT-141 a widely cited reference compound in CNS-mediated arousal and sexual function research

This communication occurs through the vagus nerve, immune system signaling, hormones, and microbial metabolites

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