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These CAFs uptake OxLDL and activate the PPARG-FABP4 axis, leading to ANGPTL4 secretion that promotes CD8+ T cell exhaustion
Marazita, M
References Campbell, R., Bellolio, F., Motosue, M., et al
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Astrocytes regulate GLP-1 receptor-mediated effects on energy balance
Because the two pathways dont compete for the same receptors, researchers have noted this as a mechanistically distinct pairing worth studying one acting directly on adipocytes, the other acting systemically through growth hormone signaling
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