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In contrast to GABA, gabapentin readily penetrates the bloodbrain barrier and rapidly increases GABA concentrations

Koehler JA, Baggio LL, Cao X, Abdulla T, Campbell JE, Secher T, Jelsing J, Larsen B, and Drucker DJ

It activates GLP-1 and GIP receptors

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the fact that the Companys product candidates may cause serious adverse events or undesirable side effects or have other properties that may cause it to suspend or discontinue clinical studies, delay or prevent regulatory development, prevent their regulatory approval, limit the commercial profile, or result in significant negative consequences