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Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: A pooled analysis of 2416 population-based measurement studies in 1289 million children, adolescents, and adults (in Eng)
Excessive amounts of free fatty acids can act directly as TLR agonists in the liver or are taken up by the liver, converted into lipotoxic intermediates that activate the JNK, IKK pathway leading to cell injury, inflammation and apoptosis (Yu et al., 2002)
It increases the proportion of slow-wave sleep (delta, 0.5-4 Hz) without suppressing REM sleep, unlike GABAergic hypnotics
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Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity