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While often discussed as a single process, inflammation involves a highly coordinated sequence of cellular events that can vary significantly depending on tissue type and experimental conditions

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The RESTORE randomized trial (N=230) demonstrated that leukocyte-rich PRP improved pain and function scores in knee osteoarthritis compared to saline at 12 months 20

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All groups, including placebo, showed some improvement, likely due to a strong placebo response and the small sample size