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Rauch F, Glorieux FH
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Two randomized controlled trials in women with hypothalamic amenorrhea have shown conflicting results: one indicated an increase in osteocalcin and N-telopeptides of type 1 collagen (NTX) but no change in BMD [102], while the other revealed increased spine BMD in lean women with hypoleptinemia [101, 103, 104]
However, it remains unknown whether it reduces the risk of cardiovascular events
Observers, however, often underestimate how non linear these changes can be
Klochkov A, Kudaravalli P, Lim Y, Sun Y
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